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Organizers |
3-string tangle analysis of Mu transposase
by
Isabel K. Darcy
University of Iowa
Coauthors: John Luecke, UT Austin; Mariel Vazquez, UC Berkeley
A tangle is a 3-dimensional ball containing a finite number of arcs and circles properly embedded in the 3-dimensional ball. A protein can be modeled using a 3-dimensional ball. If the protein binds to n segments of DNA, the n DNA segments can be thought of as n arcs embedded in the 3 dimensional protein ball. We will show how tangle analysis can be used to study any protein that stably binds DNA. In this talk, we will analyze an experiment by Pathania, Jayaram, Harshey (Cell, Vol. 109, 425-436) in which Mu Transposase binds 3 segments of DNA and a second protein, Cre recombinase, knots the DNA.
Date received: January 24, 2005
Copyright © 2005 by the author(s). The author(s) of this work and the organizers of the conference have granted their consent to include this abstract in Topology Atlas. Document # capo-08.