1. Text:
Principles of Instrumental Analysis by D. A. Skoog/F. James Holler/T. A. Nieman, published by Saunders, 5th Ed. 1997.
Call GWU Bookstore for Availability: 202-994-1439; 6873
2. References: Available at Gelman Library:
- A. Montaser, Ed., Inductively Coupled Plasma Mass Spectrometry, Wiley,
New York
, 964 pages, 1998.
- A. Montaser and D. W. Golightly, Eds. Inductively Coupled Plasmas in Analytical Atomic Spectrometry,
Wiley-VCH
,
New York
, 2nd Edition, 1992, 1017 pages.
- Spectrometric Identification of Organic Compound by Silverstein, Bassler and Morrill, published by Wiley and Sons, Fifth Edition, 1991
- Chemical Instrumentation: A Systematic Approach by Strobel and Heineman, Wiley, 3rd Edition, 1989.
3. Exams:
- Midterm #1 (33.33%); first Monday, month of October
- Midterm #2 (33.33%); first Monday, month of November
- Final (33.33%)
4. Office Hours (Prof. A. Montaser):
Tuesday & Thursday 2 ‑ 3 PM or by appointment. For appointment, please call 202‑994‑6480, or see me in Samson 211 (Office) or Cor-310 &309 (Research Laboratories), or send an Email to
montaser@gwu.edu
5. Expectations:
- Be on time.
- If you do not come to any exams due to an illness, you must bring a note from your physician.
- To get an A grade in this course, you must: 1) read the relevant chapters before coming to class; 2) take good notes during the lectures; 3) read the related chapter right after the lecture; and 4) solve the problems at the end of each chapter.
- Students are strongly encouraged to listen to all audio-cassette tapes (available in Gelman Library) related to the topics covered in this course. For example, Chem 18 (consists 52 slides and a cassette) is related to the Principle of ICP Emission Spectroscopy.
- Students must prepare a 10-page term paper (type-written) on topic related to the subjects covered in this course. The papers must be based on recent articles published in Analytical Chemistry within the last year. The students will receive free copies of Analytical Chemistry from the Instructor. An excellent term paper may add 10 extra bonus points to your overall grade (on a scale of 100).
- The Instructor welcomes all bright ideas for improving the quality of this course.
6. Tentative Course Contents: 19 Chapters
Chapter 6. An Introduction to Spectrometric Methods (1 hour).
a) General Properties of Electromagnetic Radiation
b) Wave Properties of Electromagnetic Radiation
c) Quantum - Mechanical Properties of Radiation
d) Quantitative Aspects of Spectrochemical Measurements
Chapter 7. Components of Optical Instruments (5 hours).
a) General Designs of Optical Instruments
b) Sources of Radiation
c) Wavelength Selectors
d) Sample Containers
e) Radiation Transducers
f) Signal Processors and Readouts
g) Fiber Optics
h) Types of Optical Instruments
i) Principles of Fourier Transform Optical Measurements
Chapter 8. An Introduction to Optical Atomic Spectrometry (1 hour).
a) Optical Atomic Spectra
b) Atomization Methods
c) Sample Introduction Methods
Chapter 9. Atomic Absorbtion and Atomic Flourescence Spectrometry (3 hours).
a) Sample Atomization Techniques
b) Atomic Absorption Instrumentation
c) Interferences in Atomic Absorption Spectroscopy
d) Atomic Absorption Analytical Techniques
e) Atomic Flourescence Spectroscopy
Chapter 10. Atomic Emission Spectrometry (2 hours).
a) Emission Spectroscopy Based on Plasma Sources
b) Emission Spectroscopy Based on Arc and Spark Sources
c) Miscellaneous Sources for Optical Emission Spectrometry
Chapter 11. Atomic Mass Spectrometry (2 hours).
a) Some General Features of Atomic Mass Spectrometry
b) Mass Spectrometers
c) Inductively Coupled Plasma Mass Spectrometry
d) Spark Source Mass Spectrometry
e) Glow Discharge Mass Spectrometry
Chapter 13. An Introduction of Molecular Ultraviolet/Visible Molecular Absorption Spectrometry (2 hours).
a) Measurement of Transmittance and Absorbance
b) Beer's Law
c) Effect of Instrumental Noise on Spectrophotometric Analysis
d) Instrumentation
Chapter 14. Application of Molecular Ultraviolet/Visible Absorption Spectrometry (2 hours).
a) The Magnitude of Molar Absorptivities
b) Absorbing Species
c) Application of Absorption Measurements to Qualitative Analysis
d) Quantitative Analysis by Absorption Measurement
e) Photometric Titration
f) Photoacoustic Spectroscopy
Chapter 15. Molecular Luminescence Spectrometry (1 hour).
a) Theory of Fluorescence and Phosphorescence
b) Instruments for Measurement Fluorescence and Phosphorescence
c) Applications of Photoluminescence Methods
d) Chemiluminescence
Chapter 16. An Introduction to Infrared Spectrometry (1 hour).
a) Theory of Infrared Absorption Spectrometry
b) Infrared Sources and Transducers
c) Infrared Instruments
Chapter 17. Application of Infrared Spectrometry (1.5 hours).
a) Mid-IR Absorption Spectrometry
b) Mid-IR Reflection Spectrometry
c) Photoacoustic Infrared Spectroscopy
d) Near-IR Spectroscopy
e) Far-IR Spectroscopy
f) Infrared Emission Spectroscopy
Chapter 19. Nuclear Magnetic Resonance Spectroscopy (2 hours).
a) Theory of Nuclear Magnetic Resonance
b) Environmental Effects on NMR Spectra
c) NMR Spectrometers
d) Application of Proton NMR
e) Carbon-13 NMR
f) Application of NMR to Other Nuclei
g) Two-Dimensional Fourier Transform NMR
h) Magnetic Resonance Imaging
Chapter 20. Molecular Mass Spectrometry (3 hours).
a) Molecular Mass Spectra
b) Ion Sources
c) Mass Spectrometers
d) Applications of Molecular Mass Spectrometry
e) Quantitative Applications of Mass Spectrometry
Chapter 22. An Introductory to Electroanalytical Chemistry (3 hours).
a) Electrochemical Cells
b) Potentials in Electroanalyical Cells
c) Electrode Potentials
d) Calculation of Cell Potentials from Electrode Potentials
e) Current in Cell Potentials
f) Types of Electroanalytical Methods
Chapter 23. Potentiometry (2 hours).
a) Reference Electrodes
b) Metallic Indicator Electrodes
c) Membrane Indicator Electrodes
d) Ion-Selective Field-Effect Transistors
d) Instruments for Measuring Cell Potentials
e) Direct Potentiometric Measurements
f) Potentiometric Titration
Chapter 25. Voltammetry (3 hours).
a) Excitation Signals in Voltametry
b) Voltammetric Instrumentation
c) Hydrodynamic Voltametry
d) Cyclic Voltammetry
e) Polarography
f) Stripping Methods
g) Voltammetry with Microelectrodes
Chapter 26. An Introduction to Chromatographic Separations (3 hours).
a) A General Description of Chromatography
b) Migration Rate of Species
c) Zone Broadening and Column Efficiency
d) Optimization of Column Performance
e) Summary of Important Relationships for Chromatography
f) Application of Chromatography
Chapter 27. Gas Chromatography (3 hours).
a) Principles of Gas Liquid Chromatography
b) Instruments for Gas Liquid Chromatography
c) GC Columns and the Stationary Phase
d) Applications of Gas Liquid Chromatography
e) Gas Solid Chromatography
Chapter 28. High-Performance Liquid Chromatography (2 hours)
a) Scope of HPLC
b) Column Effiency in Liquid Chromatography
c) Instrument for Liquid Chromatography
d) Partition Chromatography
e) Adsorption Chromatography
f) Ion-Exchange Chromatography
g) Size-Exclusion Chromatography
h) Thin-Layer Chromatography
