Cynthia S. Dowd, Ph.D.
Samson 303 (office)  Corcoran 301 (lab)
George Washington University
725 21st St. NW
Washington DC 20052
Tel (202) 994-8405  Fax (202) 994-5873
cdowd@gwu.edu and http://home.gwu.edu/~cdowd/

Education
		Virginia Commonwealth University, Richmond, VA
		Ph.D., Medicinal Chemistry, 1999

		University of Virginia, Charlottesville, VA
		B.A., Chemistry, 1993
		
Experience
2007-present	George Washington University, Washington, DC
		Assistant Professor, Department of Chemistry (2007-2014)
		Associate Professor, Department of Chemistry (2014-present)
Research interests include medicinal chemistry, organic synthesis, anti-infective drug design, and inhibitors of important biological processes.

2001-2007	National Institutes of Health, Rockville, MD
		Research Fellow and Chemistry Group Leader
		Supervisor:  Clifton E. Barry, III, Ph.D.

1999 – 2001	University of Pennsylvania, Philadelphia, PA
		Postdoctoral Researcher, Mentor:  Irwin M. Chaiken, Ph.D.

1994 – 1999	Virginia Commonwealth University, Richmond, VA
		Graduate Research Assistant and AFPE Predoctoral Research Fellow 
		Advisor:  Richard A. Glennon, Ph.D.
		
1993 – 1994	University of Virginia, Charlottesville, VA
		Laboratory Specialist
		
Additional Affiliations
2002-present	Virginia Commonwealth University, Richmond, VA
		Department of Nurse Anesthesia, Clinical Associate Professor

Awards and Honors
GW Academy of Distinguished Teachers, GWU, 2013-
Morton A. Bender Teaching Award, GWU, 2011
NIH Director’s Award, 2007
NIAID Merit and Service Award, NIAID, 2005 and 2006
Leadership Development Award from ACS Younger Chemists’ Committee, 2002
Predoctoral Fellowship, Amer. Foundation for Pharmaceutical Educ., 1996-1999
Travel Grant from the ACS: Medicinal Chemistry Division, 1998
Travel Grant from the ACS: Women Chemists’ Committee, 1998
Outstanding Graduate Student, Medicinal Chemistry, VCU, 1999
Outstanding Graduate Student, School of Pharmacy, VCU, 1999
Outstanding Oral Presentation, Virginia Academy of Sciences, 1999

Teaching Experience
2007-present	George Washington University, Washington DC
		Department of Chemistry, Organic Chemistry (Chem 2152); spring semesters
		Department of Chemistry, Advanced Organic Chemistry (Chem 6251); fall semesters
		Department of Biochemistry, Structure and Function of Proteins (Biochem 6234); lecturer 
		
2003	Virginia Commonwealth University, Richmond, VA
		Guest Lecturer in “Organic Chemistry for Nurse Anesthetists”
		Department of Nurse Anesthesia
					
1994 – 1999	Virginia Commonwealth University, Richmond, VA
		Graduate Teaching Assistant
Lecturer in “Medicinal Chemistry for Nurse Anesthesia” graduate course.
Tutor in organic chemistry for nurse anesthesia students.
Teaching assistant for “Drug Analysis” laboratory for pharmacy graduate students.

Membership and Service
Gamow Fellowship Selection Committee, GWU, 2011-present
Mid-Atlantic Regional Meeting (MARM) of ACS, session chair, 2012
Bender Award Selection Committee, GWU, 2012
Grant Reviewer, NIH, ad hoc, 2010 (DDR), 2011 (SBIR)
Grant Reviewer, NSF, 2013
Faculty Recruitment, GWU, Physics, Chemistry, University Professor, 2010-13
Judge, GW Research Day, 2012
Grant Reviewer, Biotechnology Research Grant Program, NC Biotechnology Center, 2009
Selection Committee and faculty mentor, REU program, GWU, 2009
Graduate Recruitment, GWU, Chemistry, 2009-present
			Scholarship Advisor, Phi Alpha chapter of Chi Omega Fraternity, GWU, 2008-present
Manuscript Reviewer for Journal of Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Bioorganic and Medicinal Chemistry, Journal of Biological Chemistry, Tetrahedron, Biochemistry, European Journal of Medicinal Chemistry, Chemical Biology and Drug Design, Journal of Combinatorial Chemistry, Organic Letters, Antimicrobial Agents and Chemotherapy, Bioconjugate Chemistry, PLos One, MedChemComm:  2005-present
American Chemical Society (National, Medicinal and Organic Divisions):  1995-present Introduction to Biomedical Research Program, participant scientist, NIAID/NIH:  2002
Postdoctoral Council, University of Pennsylvania:  1999-2001
Faculty Promotion Committee, Virginia Commonwealth University:  1998

Publications—journal (peer-reviewed)

33.  Chofor, R.; Risseeuw, M.; Pouyez, J.; Johny, C.; Haymond, A.; Everaert, A.; Dowd, C.; Maes, L.; Coenye, T.; Alex, A.; Couch, R.; Wouters, J.; Van Calenbergh, S. Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase, submitted.
32. Haymond, A.; Johny, C.; Dowdy, T.; Schweibenz, B.; Villarroel, K.; Young, R.; San Jose, G.; Jackson, E.R.; Dowd, C.S.; Couch, R.D. Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase), PLoS One, 2014, 9(8), e106243. doi: 10.1371/journal.pone.0106243. PMID: 25171339. 
31. Ibekwe, N.N.; Nvau, J.B.; Oladosu, P.O.; Usman, A.M.; Ibrahim, K.; Boshoff, H.I.; Dowd, C.S.; Orishadipe, A.T.; Aiyelaagbe, O.; Adesomoju, A.A.  Barry, 3rd, C.E.; Okogun, J.I. in collaboration with 73 Visited Herbalists. Some Nigerian Anti-Tuberculosis Ethnomedicines:  A Preliminary Efficacy Assessment, J. Ethnopharmacology, 2014, 155(1), 524-532.  doi: 10.1016/j.jep.2014.05.059.  PMID: 24911338
30.	Chofor, R.; Risseeuw, M.D.P.; Pouyez, J.; Johny, C.; Wouters, J.; Dowd, C.S.; Couch, R.D.; Van Calenbergh, S. Synthesis and evaluation of fosmidomycin analogues with altered chelating moieties as inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, Molecules, 2014, 19, 2571-2587.  doi:10.3390/molecules19022571. PMID: 24566322
29.	Jackson, E.R.; San Jose, G.; Brothers, R.C.; Edelstein, E.K.; Sheldon, Z.; Haymond, A.; Johny, C.; Boshoff, H.I.; Couch, R.D.; Dowd, C.S.*  The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs, Bioorg. Med. Chem. Lett., 2014, 24(2), 649-653.  doi: 10.1016/j.bmcl.2013.11.067.  PMID: 24360562

28.	San Jose, G.; Jackson, E.R.; Uh, E.; Johny, C.; Haymond, A.; Lundberg, L.; Pinkham, C.; Kehn-Hall, K.; Boshoff, H.I.; Couch, R.D.; Dowd, C.S.*  Design of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)—Evidence of a Novel Binding Mode, MedChemComm, 2013, 4(7), 1099-1104.  PMID: 23914289

27.	McKenney, E.S.; Sargent, M.; Khan, H.; Couch, R.D.; Uh, E.; Jackson, E.R.; San Jose, G.; Dowd, C.S.; van Hoek, M.L.  Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy, PLoS One, 2012, 7(10): e38167.  PMID: 23077474

26.	Jackson, E.J.; Dowd, C.S.*  Inhibitors of 1-Deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr): A Review of the Synthesis and Biological Evaluation of Recent Inhibitors, Curr. Topics Med. Chem., 2012, 12, 706-728.  PMID: 22283814

25.	Gurumurthy, M.; Mukherjee, T.; Dowd, C.S.; Singh, R.; Niyomrattanakit, P.; Tay, J.; Nayyar, A.; Lee, Y.S.; Cherian, J.; Boshoff, H.I.; Dick, T.; Barry, 3rd, C.E.; Manjunatha, U.H.  Substrate specificity of the Deazaflavin-Dependent Nitroreductase (Ddn) from Mycobacterium tuberculosis Responsible for the Bioreductive Activation of Bicyclic Nitroimidazoles, FEBS J., 2012, 279(1), 113-125.  doi: 10.1111/j.1742-4658.2011.08404.x.  PMID: 22023140

24.	Uh, E.; Jackson, E.R.; San Jose, G.; Maddox, M.; Lee, R.E.; Lee, R.E.; Boshoff, H.I.; Dowd, C.S.*  Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs, Bioorg. Med. Chem. Lett., 2011, 21, 6973-6976; doi: 10.1016/j.bmcl.2011.09.123.  PMID: 22024034

23.	Bollo, S.; Nunez-Vergara, L.J.; Kang, S.; Zhang, L.; Boshoff, H.I.; Barry, III, C.E.; Squella, J.A.; Dowd, C.S.* The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824, Bioorg. Med. Chem. Lett., 2011, 21, 812-817.  PMID: 21168331

22.	Guendel, I.; Carpio, L.; Easley, R.; Van Duyne, R.; Coley, W.; Agbottah, E.; Dowd, C.; Kashanchi, F.; Kehn-Hall, K.  9-aminoacridine Inhibition of HIV-1 Tat Dependent Transcription, Virology Journal, 2009, 6, 114.

21.	Kim, P.; Kang, S.; Boshoff, H.I.; Jiricek, J.; Collins, M.; Singh, R.; Manjunatha, U.H.; Niyomrattanakit, P.; Zhang, L.; Goodwin, M.; Dick, T.; Keller, T.H.; Dowd, C.S.*; Barry, III, C.E.*  Structure-Activity Relationships of Antitubercular Nitroimidazoles.  II. Determinants of aerobic activity and quantitative structure-activity relationships, J. Med. Chem. 2009, 52, 1329-1344.

20.	Kim, P.; Zhang, L.; Manjunatha, U.H.; Singh, R.; Patel, S.; Jiricek, J.; Keller, T.H.; Boshoff, H.I.; Barry, III, C.E.; Dowd, C.S.*  Structure-activity relationships of antitubercular nitroimidazoles. I. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles, J. Med. Chem. 2009, 52, 1317-1328.

19.	Singh, R.; Manjunatha, U.; Boshoff, H.I.M.; Ha, Y.H.; Niyomrattanakit, P.; Ledwidge, R.; Dowd, C.S.; Lee, I.Y.; Kim, P.; Zhang, L.; Kang, S.; Keller, T.H.; Jiricek, J.; Barry, III, C.E. PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release, Science, 2008, 322, 1392-1395. 

18.	Boshoff, H.I.M.; Xu, X.; Tahlan, K.; Dowd, C.S.; Pethe, K.; Camacho, L.R.; Park, T.-H.; Yun, C.-S.; Schnappinger, D.; Ehrt, S.; Williams, K.; Barry, III, C.E.  Biosynthesis and recycling of nicotimamide cofactors in Mycobacterium tuberculosis:  an essential role for NAD in non-replicating bacilli, J. Biol. Chem. 2008, 283, 19329-19341.

17.	Li, X.; Manjunatha, U.H.; Goodwin, M.B.; Knox, J.E.; Lipinski, C.; Keller, T.H.; Barry, III, C.E.; Dowd, C.S.* Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824, Bioorg. Med. Chem. Lett. 2008, 18, 2256-2262.

16.	Wu, W.; Kehn-Hall, K; Pedati, C.; Zweier, L.; Castro, I.; Klase, Z.; Dowd, C.S.; Dubrovsky, L.; Bukrinsky, M.; Kashanchi, F.  Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 Progeny Formation, Virology Journal 2008, 5, 41.

15.	Goodwin, M.; Boshoff, H.I.; Barry, III, C.E.; Dowd C.S.* Quantification of small molecule organic acids from Mycobacterium tuberculosis culture supernatant using ion exclusion liquid chromatography/mass spectrometry.  Rapid Commun. Mass Spec. 2006, 20, 3345-3350.

14.	Manjunatha, U.H.; Lahiri, R.; Randhawa, B.; Dowd, C.S.; Krahenbuhl, J.; Barry, III, C.E.; Mycobacterium leprae is naturally resistant to PA-824.  Antimicrob. Agents Chemother. 2006, 50, 3350-3354.

13.	Kim, P.; Barry, III, C.E.; Dowd, C.S.*  Novel route to 5-position vinyl derivatives of thiolactomycin:  olefination vs. deformylation.  Tetrahedron Lett. 2006, 47, 3447-3451.

12.	Manjunatha, U.H.; Boshoff, H.I.; Dowd, C.S.; Zhang, L.; Albert, T.J.; Norton, J.E.; Pang, S.S.; Dick, T.; Daniels, L.; Barry, III, C.E. Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. 2006, 103, 431-436.

11.	Kim, P.; Zhang, Y.M.; Shenoy, G.; Nguyen, Q.A.; Boshoff, H.I.; Manjunatha, U.H.; Goodwin, M.; Lonsdale, J.; Price, A.C.; Miller, D.J.; Duncan, K.; White, S.W.; Rock, C.O.; Barry, III, C.E.; Dowd, C.S.*  Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli. J. Med. Chem. 2006, 49, 159-171.

10.	Shenoy, G.; Kim, P.; Goodwin, M.; Nguyen, Q.–A.; Barry, 3rd, C.E.; Dowd, C.S.*  Synthesis and spectroscopic differentiation of 2- and 4-alkoxythiotetronic acids.  Heterocycles 2004, 63, 519-527.  

9.	Barry, 3rd, C.E.; Boshoff, H.I.M.; Dowd, C.S.  Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis.  Curr. Pharmaceutical Des. 2004, 10, 3239-3262.

8.	Cherukuri, A.; Carter, R.; Brooks, S.; Bornmann, W.; Finn, R.; Dowd, C.S.; Pierce, S.K.  B cell signaling is regulated by induced palmitoylation of CD81.  J. Biol. Chem. 2004, 279, 31973-31982.

7.	Domenech, P.; Reed, M.B.; Dowd, C.S.; Manca, C.; Kaplan, G.; Barry, 3rd, C.E.  The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis.  J. Biol. Chem. 2004, 279, 21257-21265.

6.	Dowd, C.S.; Leavitt, S.; Babcock, G.; Godillot, A.P.; Van Ryk, D.; Canziani, G.A.; Sodroski, J.; Freire, E.; Chaiken, I.M.  -Turn Phe in HIV-1 Env binding site of CD4 and CD4 mimetic miniprotein enhances Env binding affinity but is not required for activation of co-receptor/17b site.  Biochemistry 2002, 41, 7038-7046.

5.	Li, C.†; Dowd, C.S.†; Zhang, W.; Chaiken, I.M. Phage randomization in a charybdotoxin scaffold leads to CD4-mimetic recognition motifs that bind HIV-1 envelope through non-aromatic sequences.  J. Peptide Res. 2001, 57, 507-518.  †contributed equally

4.	Dowd, C.S.; Zhang, W.; Li, C.; Chaiken, I.M. From receptor recognition mechanisms to bioinspired mimetic antagonists in HIV-1/cell docking. J. Chromatography B 2001, 753, 327-335.

3.	Rangisetty, J.B.; Dukat, M.; Dowd, C.S.; Herrick-Davis, K.; DuPre, A.; Gadepalli, S.; Teitler, M.; Kelley, C.R.; Sharif, N.A.; Glennon, R.A.  1-[2-Methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT2A serotonin receptor affinity and antagonist character.  J. Med. Chem. 2001, 44, 3283-3291.

2.	Dowd, C.S.; Herrick-Davis, K.; Egan, C.; DuPre, A.; Smith, C.; Teitler, M.; Glennon, R.A. 1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT2A partial agonists. J. Med. Chem. 2000, 43, 3074-3084.

1.	Teitler, M.; Schieck, C.; Howard, P.; Sullivan, J.E., III; Iwamura, T.; Glennon, R.A. 5-HT2A serotonin receptor binding: a preliminary structure-affinity investigation. Med. Chem. Res. 1997, 7, 207-218. (Note: Name spelled Scheick in published article.)

*corresponding author

Publications—book/chapter

C.S. Dowd and L.B. Kier, editors and principal authors, The Chemistry and Physics of Drugs Used in Anesthesia, American Association of Nurse Anesthetists, Park Ridge, IL, 2014.

H.I. Boshoff and C.S. Dowd.  Chemical Genetics: an evolving toolbox for target identification and lead optimization, In Applications of functional genomics and systems biology to the development of anti-infectives, H.I. Boshoff and C.E. Barry III, Eds.; Progress in Drug Research Series, Birkhäuser Publishing Ltd.; Cambridge, MA, 2007.

L.B. Kier and C.S. Dowd, editors and principal authors. The Chemistry of Drugs for Nurse Anesthetists, American Association of Nurse Anesthetists, Park Ridge, IL, 2004.

I.M. Chaiken; S.-J. Wu; C. Plugariu; W. Zhang; C. Li; C.S. Dowd. Convergence of Recombinant Mutagenesis and Kinetics Interaction Analysis for Revealing Receptor Recognition Mechanisms and Designing Receptor Ligands, In Thermodynamics of Drug-Receptor Interactions, R. Raffa, Ed.; John Wiley & Sons; New York, 2001.

Patents

Jiricek, J.; Patel, S.; Keller, T.H.; Barry, III, C.E.; Dowd, C.S.  Preparation of nitroimidazole compounds useful in the treatment of infections caused by Mycobacterium tuberculosis, Trypanosoma cruzi or Leishmania donovani.    PCT Int. Appl.  (2007) WO2007075872.

Boshoff, H.I.; Dowd, C.S.; Jackson, E.R.; Kehn-Hall, K.; Lee, R.E.; Lee. R.; San Jose, G.  Compounds for inhibiting 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Provisional Patent Application (2011) USPTO 61/503,736.

Media coverage and participation

“A New Target in the Fight Against TB” by Danny Freedman, Untrodden Ground (GWU Research Blog) 2013. 
http://www.gwresearchblog.com/2013/07/01/a-new-target-in-the-fight-against-tb/#more-2346. Also appears in GW Today (http://gwtoday.gwu.edu/new-target-fight-against-tb).

GW Expert Series 2012, Research highlighted on WJLA ABC: http://www.youtube.com/watch?v=ne5HAXlaF_4

ColonialCast Faculty Testimonial--CITL, GWU.  Presented at the 2012 Educause National Conference, Denver, CO.  GW contact: Yordanos Baharu.  https://www.youtube.com/watch?v=IcArkSfjNH8

“Conversations:  Collaboration”, 2011, Faculty and leadership discuss collaboration across disciplines in the new GWU Science and Engineering Hall, http://giving.gwu.edu/science-engineering-hall

Video for Colonial Inauguration, as requested by CCAS Dean and Department Chair, April 2009.

Interviewed for Chemical & Engineering News article on scientific publishing, C&EN 2007, 85 (33), 46-49.

Research Support

Ongoing Research Support 
Columbian College Facilitating Fund, George Washington University	07/01/14-06/30/15
Title:  A novel class of Dxr inhibitors against TB and other human pathogens
Goal:  To synthesize and evaluate a new class of compounds as novel antibiotics; $7,300.
Role:  PI

University Facilitating Fund, George Washington University		07/01/13 – 06/30/14
Title:  NAD synthetase inhibitors as novel antitubercular agents
Goal:  To synthesize and evaluate novel NAD inhibitors for antiMtb activity; $14,991.
Role:  PI

Completed Research Support
DC-D-CFAR, George Washington University				11/1/12
Title:  Boronyl dipeptides as inhibitors of HIV infectivity and the human proteasome
Goal:  To investigate the cross-over activity of novel antitubercular boronyl dipeptides; $2,500.
Role:  PI

University Facilitating Fund, George Washington University		07/01/11 – 06/30/12
Title:  Synthesis of Small Molecule Inhibitors of the Mycobacterium tuberculosis Proteasome
Goal:  Continue the synthesis and evaluation of Mtb inhibitors using the proteasomal pathway; $11,141.
Role:  PI

RC1 AI086453 (NIAID/NIH) 		Dowd (PI)			09/26/09 – 08/31/12 
Title:  Inhibitors of the nonmevalonate pathway to kill Mycobacterium tuberculosis
Goal:  Using structure-based design, to design, synthesize and evaluate novel small molecules as inhibitors of the nonmevalonate pathway (via Dxr) in Mtb; $721,525.
Role:  PI

University Facilitating Fund, George Washington University		07/01/10 – 06/30/11
Title:  Systematic investigation of the ligand binding requirements of the Mtb proteasome
Goal:  To synthesize and evaluate small molecule inhibitors of Mtb via the proteasomal pathway; $16,248.
Role:  PI

University Facilitating Fund, George Washington University		07/01/08 – 06/30/09
Title:  Chemical Tools to Target Latent Mycobacterium Tuberculosis:  Inhibitors of Dxr
Goal:  To synthesize and evaluate small molecules as inhibitors of Mtb via the nonmevalonate pathway; $16,579.
Role:  PI

University Seed Grant, George Washington University			01/01/08 – 12/31/08
Title: Small molecule libraries to find lead compounds for important biological problems
Goal: To use small molecule chemical libraries to find novel inhibitors of processes related to Mtb and HIV; $50,000 (Dowd portion: $24,945).
Role:  Co-PI (with Fatah Kashanchi)


Invited Presentations
30.  Department of Medicinal Chemistry, University of Maryland Baltimore, April 2014.
29.  Department of Chemistry, Virginia Commonwealth University, February 2014.
28.  Department of Medicinal Chemistry, University of Minnesota, January 2014.
27.  Frontiers at the Chemistry-Biology Interface Symposium, UMD College Park, May 2013.
26.  Department of Chemistry, University of Maryland Baltimore County, April 2013.
25.  Department of Chemistry, Catholic University, Washington DC, November 2012.
24.  Department of Chemistry & Biochemistry, University of Maryland College Park, September 2012.
23.  University of Ghent (Belgium), June 2012.
22.  Mid-Atlantic Regional Meeting (MARM) of the ACS, May 2012.
21.  School Without Walls, Washington DC, February 2012.
20.  Department of Chemistry, St. Mary’s College, November 2011.
19.  FORWARD meeting, Gallaudet University, panelist, May 2011.
18.  Model United Nations, WHO group, March 2011.
17.  Department of Microbiology, Immunology and Tropical Medicine, GWUMC, February 2011.
16.  Department of Chemistry, George Mason University, May 2010.
15.  CCAS Research Team Meeting, GWU, March 2010.
14.  National Biodefense Center, George Mason University, December 2009.
13.  Department of Chemistry, Shippensburg University, March 2009.
12.  Department of Health Sciences, Ferrum College, March 2008.
11.  Departmental retreat, Department of Chemistry, GWU, September 2007.
10.  Tuberculosis Drug Development Gordon Research Conference, Oxford, UK, August 2007.
9.  NIDDK Chemistry Seminar Series, NIH, Bethesda, MD, 2006.
8.  Department of Pharmaceutical Sciences, Oregon State University, 2005.
7.  NITD Symposium on Tuberculosis, Bagamoyo, Tanzania, 2005.
6.  NIH International TB Working Group, NIH, Bethesda, MD, 2005.
5.  Eighteenth Symposium of the Protein Society, San Diego, CA, 2004.
4.  Tuberculosis Drug Development Gordon Research Conference, Oxford, UK, 2003.
3.  National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Nigeria, 2002.
2.  St. Jude Children’s Research Hospital, Memphis, TN, 2001.
1.  The Intravenous Nurses Society, New York City Metro Area Chapter, Mineola, NY, 2000.


Selected Poster Presentations
Dowd, C.S.; San Jose, G.; Jackson, E.J.; Haymond, A.; Johny, C.; Boshoff, H.I.; Couch, R.D. Synthesis and Evaluation of FR900098 Analogs as M. tuberculosis and Y. pestis Dxr (IspC) Inhibitors, Bioorganic Chemistry Gordon Research Conference, June 2014.

Clements, G.V.; Boshoff, H.I.; Lin, G.; Dowd, C.S. Design and Synthesis of Boronyl Dipeptides as 
Mycobacterium tuberculosis Proteasome Inhibitors, Bioorganic Chemistry Gordon Research Conference, June 2014.

Clements, G.V.; Yepikhin, A.S.; Boshoff, H.I.; Dowd, C.S. Mycobacterium tuberculosis Proteasome Inhibitors, Frontiers at the Chemistry-Biology Interface Symposium, University of Maryland College Park, May 2013.

Clements, G.V.; Yepikhin, A.S.; Boshoff, H.I.; Dowd, C.S. Mycobacterium tuberculosis Proteasome Inhibitors, Abstracts of Papers, 245th National Meeting of the ACS, New Orleans, LA; American Chemical Society:  Washington DC, April 2013, MEDI 81.

Titzell, C.M.; Jackson, E.R.; Uh, E.; Dowd, C.S. Small Molecule Inhibition of Mycobacterium tuberculosis Enzyme DXR, DC STEM Science Fair, March 2013. 2nd Place Grand Award Winner (Senior division). Re-presented DC at the International Science and Engineering Fair (ISEF), Phoenix, AZ, May 2013.

San Jose, G.; Hill, L.; Kehn-Hall, K.; Boshoff, H.I.; Lee, R.E.; Dowd, C.S.  Design, Synthesis and Biological Evaluation of Novel Mtb-specific Dxr Inhibitors as Potential Anti-Tubercular Agents, Abstracts of Papers, 242st National Meeting of the ACS, Denver, CO; American Chemical Society:  Washington DC, 2011, MEDI 110.

Jackson, E.R.; San Jose, G.; Hill, L.; Kehn-Hall, K.; Dowd, C.S.  Design, Synthesis and Evaluation of Mtb Dxr Structure-Based Inhibitors, Gordon Research Conference, Tuberculosis Drug Development, Lucca (Barga) Italy, 2011.

Uh, E.; Jackson, E.R.; San Jose, G.; McKenney, E.; Maddox, M.; Lee, R.; van Hoek, M.; Boshoff, H.I.; Lee, R.; Dowd, C.S.  Antibacterial activity of lipophilic esters of Mtb Dxr inhibitors, Gordon Research Conference, Tuberculosis Drug Development, Lucca (Barga) Italy, 2011.

McKenney, E.; Uh, E.; Jackson, E.R.; San Jose, G.; Dowd, C.S.; Van Hoek, M. The Use of Fosmidomycin Derivatives Against Francisella tularensis subsp. Novicida, Mid-Atlantic Microbial Pathogenesis Meeting, Wintergreen VA, 2011.

McKenney, E.; Uh, E.; Jackson, E.R.; San Jose, G.; Couch, R.; Dowd, C.S.; Van Hoek, M.  Fosmidomycin and Derivatives as Antimicrobial agents Against Francisella tularensis subsp. novicida, American Society for Microbiology Meeting, Washington DC, 2011.

Kim, P.; Zhang, L.; Manjunatha, U.H.; Singh, R.; Patel, S.; Jiricek, J.; Keller, T.H.; Boshoff, H.I.; Barry, C.E.; Dowd, C.S. SAR of antitubercular nitroimidazoles: Aerobic and anaerobic activities of 4-and 5-nitroimidazoles, Pacifichem 2010, International Chemical Congress of Pacific Basin Societies, Honolulu, HI, 2010, HEALTH-288.

Jackson, E.R.; Kehn-Hall, K.; Boshoff, H.I.; Kashanchi, F.; Dowd, C.S. Small Molecules to Target Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate reducto-isomerase (MtbDxr), Abstracts of Papers, 240th National Meeting of the ACS, Boston, MA; American Chemical Society:  Washington DC, 2010, MEDI 141.

Clements, G.V.; Boshoff, H.I.; Dowd, C.S. Design and Synthesis of Prokaryotic Proteasome Inhibitors, Abstracts of Papers, 240th National Meeting of the ACS, Boston, MA; American Chemical Society:  Washington DC, 2010, MEDI 470.

San Jose, G.; Kehn-Hall, K.; Boshoff, H.I.; Kashanchi, F.; Dowd, C.S. Synthesis of small molecule inhibitors of Mtb Dxr from Mycobacterium tuberculosis, Abstracts of Papers, 240th National Meeting of the ACS, Boston, MA; American Chemical Society:  Washington DC, 2010, MEDI 374.

Uh, E.; Jackson, E.R.; Boshoff, H.I.; Dowd, C.S.  Synthesis of Analogs of FR900098 to inhibit Mycobacterium Tuberculosis 1-Deoxy-D-xylulose-5-phosphate reducto-isomerase (MtbDxr).  3rd Annual Mid-Atlantic Frontiers at the Chemistry - Biology Interface Symposium, Johns Hopkins University, May 2010.

Jackson, E.R.; Hirst, E.S.; Izadpanah, N.; Butler, S.; Bruno, K.; Kehn-Hall, K.; Boshoff, H.I.; Kashanchi, F.; Dowd, C.S. Small Molecules to Inhibit Mycobacterium Tuberculosis Dxr. 2nd Annual Mid-Atlantic Frontiers at the Chemistry - Biology Interface Symposium, University of Maryland, Baltimore County, May 2009.

Jackson, E.R.; Kehn-Hall, K.; Boshoff, H.I.; Kashanchi, F.; Dowd, C.S. Novel Synthesis of Small Molecules to Target Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate reducto-isomerase (Dxr).  Chemical Insights into Biological Processes Symposium, August 15-16, 2008, Frederick, Maryland.  Sponsored by the Center for Cancer Research and the Chemistry and Structural Biology Faculty of the NCI, NIH. 

Kim, P.; Manjunatha, U.; Barry, III, C.E.; Dowd, C.S.  Synthesis and potency of PA-824 and metronidazole analogs as probes for anaerobic vs. aerobic activity against Mycobacterium tuberculosis.    Abstracts of Papers, 233rd National Meeting of the American Chemical Society, Chicago, IL; American Chemical Society:  Washington DC, 2007, MEDI 046.

Kim, P.; Zhang, Y.M.; Shenoy, G.; Manjunatha, U.; Boshoff, H.; Nguyen, Q.A.; Goodwin, M.; Miller, D.; White, S.; Duncan, K.; Rock, C.O.; Barry, III, C.E.; Dowd, C.S. Synthesis of 4-position hydrophilic derivatives of thiolactomycin as antitubercular agents.  Abstracts of Papers, 230th National Meeting of the American Chemical Society, Washington DC; American Chemical Society:  Washington DC, 2005, MEDI 457.

Goodwin, M.B.; Boshoff, H.; Dowd, C.S.; Barry, III, C.E. Quantification of cellular small molecule organic acids using ion exclusion LC/MS.  Abstracts of Papers, 230th National Meeting of the American Chemical Society, Washington DC; American Chemical Society:  Washington DC, 2005, ANYL 159. 

Kim, P.; Zhang, Y.M.; Shenoy, G.; Nguyen, Q.A.; Boshoff, H.I.; Manjunatha, U.; Goodwin, M.B.; Lonsdale, J.; Price, A.C.; Duncan, K; White, S.W.; Rock, C.O.; Barry, III, C.E.; Dowd, C.S.  Thiolactomycin:  The Importance of the Isoprene Side Chain Against KasA/B in Mycobacterium tuberculosis.  Gordon Research Conference on Tuberculosis Drug Development, University of New England, Biddeford, Maine, 2005.

Zhang, L.; Manjunatha, U.; Goodwin, M.B.; Keller, T.; Dowd, C.S.; Barry, III, C.E.  Structural Variants of PA-824 as Potential Antitubercular Agents.  Gordon Research Conference on Tuberculosis Drug Development, University of New England, Biddeford, Maine, 2005.

Kim, P.; Shenoy, G.; Nguyen, Q.A.; Goodwin, M.; Dowd, C.S.; Barry III, C.E. Synthesis of racemic thiolactomycin (TLM) and its C(5) derivatives. Abstracts of Papers, 225th National Meeting of the American Chemical Society, New Orleans, LA; American Chemical Society:  Washington DC, 2003, ORGN 288.

Dowd, C.S.; Li, C.; Chaiken, I.M. CD4 mimetic peptides and the mechanism of HIV entry. Abstracts of Papers, 221st National Meeting of the American Chemical Society, San Diego, CA; American Chemical Society: Washington DC, 2001, MEDI 114.

Lee, K.S.; Zhang, L.; Schieck-Dowd, C.; Jones, D.W.; Gorey, J.G.; Glennon, R.A.; Weinberger, D.R. Estrogen upregulates 5HT2 binding activity in the frontal cortex of rats.  Presented at the 48th Annual Meeting of The Society for Nuclear Medicine, 2001.  J. Nucl. Med. 2001, 42, Suppl. S (#397).

Lee, K.S.; Jones, D.W.; Eckelman, W.C.; Adams, D.; Gorey, J.G.; Schieck, C.L.; Glennon, R.A.; Weinberger, D.R. An Optimal Radiobromination Method for Stannylated Ligands for PET Imaging.  Presented at the 47th Annual Meeting of The Society for Nuclear Medicine, 2000.

Lee, K.S.; Zhang, L.; Schieck, C.L.; Jones, D.W.; Eckelman, W.C.; Gorey, J.G.; Adams, H.R.; Glennon, R.A.; Weinberger, D.R. Autoradiography of R(-)-[Br-76]DOB, a Potent 5-HT2A/2C Serotonin Receptor Agonist, in Rat Brain.  Presented at the 47th Annual Meeting of The Society for Nuclear Medicine, 2000.  J. Nucl. Med. 2000, 41, Suppl. S. (#1069).

Schieck, C.L.; Lee, K.S.; Jones, D.W.; Gorey, J.G.; Saunders, R.C.; Urbina, R.A.; Knable, M.B.; Weinberger, D.R.; Glennon, R.A.  [123I]-DOI: A novel 5-HT2 receptor SPECT imaging agent.  Abstracts of Papers, 217th National Meeting of the American Chemical Society, Anaheim, CA; American Chemical Society: Washington DC, 1999, MEDI 247.mailto:cdowd@gwu.eduhttp://home.gwu.edu/~cdowd/http://www.gwresearchblog.com/2013/07/01/a-new-target-in-the-fight-against-tb/#more-2346http://gwtoday.gwu.edu/new-target-fight-against-tbhttp://www.youtube.com/watch?v=ne5HAXlaF_4https://www.youtube.com/watch?v=IcArkSfjNH8http://giving.gwu.edu/science-engineering-hallshapeimage_2_link_0shapeimage_2_link_1shapeimage_2_link_2shapeimage_2_link_3shapeimage_2_link_4shapeimage_2_link_5shapeimage_2_link_6

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