Bindesh Shrestha - George Washington University

Bindesh Shrestha
Research Assistant
Department of Chemistry
George Washington University

Graduate Advisor

Professor Akos Vertes
http://www.gwu.edu/~vertes/
http://www.gwu.edu/~ipta/

Research Interest

My research interest includes the fundamentals and applications of soft-ionization mass spectrometry to solve biological problems. I am currently interested in infrared-laser based ambient soft-ionization techniques such as atmospheric pressure (AP) infrared (IR) matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to perform direct and rapid in situ analysis of biomolecules, such as metabolites and lipids, present in tissue. Other areas of my interest include broader aspects of mass spectrometric and related techniques such 2D gel electrophoresis, HPLC, GC, ion mobility spectrometry, etc.

Contact Information

Email: bindesh (at) gwu.edu
Phone: 994 6344

Office/Lab

Room 407, Corcoran Hall
725 21st Street, NW Washington, DC 20052

Presentations

Shrestha, B.; Nemes, P.; Nazarian, J.; Hoffman, E.; Vertes, A. Direct analysis of lipids and other metabolites in mouse brain tissue with infrared laser ablation and mass spectrometry., Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, June 1-June 6, 2008. | Abstract | Poster |

Shrestha, B.; Li, Y.; Vertes, A. Rapid Analysis of Pharmaceuticals and their Metabolites with Atmospheric Pressure Infrared MALDI Mass Spectrometry., Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, IN, June 3-June 7, 2007;DVD-ROM. | Abstract | Poster |

Li, Y.; Shrestha, B.; Vertes, A. Atmospheric Pressure Infrared MALDI Mass Spectrometry: Imaging and In Vivo Studies of Metabolites in Plants., Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, IN, June 3-June 7, 2007;DVD-ROM. | Abstract |

Shrestha, B.; Li, Y.; Vertes, A. Direct analysis of drugs and their metabolites by infrared atmospheric pressure matrix-assisted laser desorption ionization mass spectrometry., FACSS 2006 Conference, Orlando FL, September 24 - 28, 2006 | Abstract | Poster |

Li, Y.; Shrestha, B.; Vertes, A. Imaging at Atmospheric Pressure by MALDI Mass Spectrometry. Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics, Seattle, WA, May 28-June 1, 2006;DVD-ROM. | Abstract | Poster |

Nazarian, J.; Shrestha, B.; Hathout, Y.; Vertes, A. ; Hoffman, E. Proteomic Analyses of Torpedo Californica Electroplaque as a Model for The Neuromuscular Junction. Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics, Seattle, WA, May 28-June 1, 2006;DVD-ROM. | Poster |

Last Updated: August 26, 2008

about me

I am a graduate student at the Chemistry Department of the George Washington University (GWU), Washington DC. My graduate advisor is Professor Akos Vertes.

Before enrolling in GWU, I graduated from Moravian College , Bethlehem , PA with double major in Chemistry and Economics.

highlights

March 2008

Biophotonics featured a report on metabolite analysis by AP IR-MALDI - Deeper Into The Plant Kingdom .

January 2008

Our article was featured on the cover page of the Analytical Chemistry (January 15, 2008 / Volume 80 / Issue 2).

Papers

B. Shrestha, Y. Li and A. Vertes, “Rapid analysis of pharmaceuticals and excreted xenobiotic and endogenous metabolites with atmospheric pressure infrared MALDI mass spectrometry,” Metabolomics, 2008, DOI 10.1007/s11306-008-0120-8.

A. Vertes, P. Nemes, B. Shrestha, A. A. Barton, Z. Chen and Y. Li,”Molecular Imaging by Mid-IR Laser Ablation Mass Spectrometry,” Appl. Phys. A, 2008, DOI 10.1007/s00339-008-4750-5.

Y. Li, B. Shrestha and A. Vertes, “Atmospheric Pressure Infrared MALDI Imaging Mass Spectrometry for Plant Metabolomics,” Anal. Chem., 2008, 80, 407-420.

Y. Li, B. Shrestha and A. Vertes, "Atmospheric Pressure Molecular Imaging by Infrared MALDI Mass Spectrometry," Anal. Chem.,2007, 79, 523-532.

Any comments, email me at bindesh(AT)gwu.edu