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Last Updated: February 9, 2009  

Bindesh Shrestha
Research Assistant
Department of Chemistry
George Washington University

Research Director

Professor Akos Vertes
http://www.gwu.edu/~vertes/
http://www.gwu.edu/~ipta/

Research Interest

My research interest includes the fundamentals and applications of soft-ionization mass spectrometry to solve biological problems. I am currently interested in infrared-laser based ambient soft-ionization techniques, such as Laser ablation electrospray ionization (LAESI)and atmospheric pressure (AP) infrared (IR) matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, to perform direct and rapid in situ analysis of metabolites and lipids in tissue.

Contact Information

Email: bindesh (at) gwmail.gwu.edu
Phone: 994 6344 (Area code 202)

Office/Lab

Vertes Research Laboratory 407, Corcoran Hall
725 21st Street, NW Washington, DC 20052

Conference Proceedings*

B. Shrestha,P. Nemes, P. Sripadi, J. Nazarian, Y. Hathout, S. Trikha, A. Jeremic, E. P. Hoffman, S. A. Moody and A. Vertes, “Lipid analysis from amphibian eggs, cell pellets and tissues by reactive LAESI mass spectrometry”, Proceedings of the 21st ASMS Sanibel Conference "Lipidomics and Lipids in Mass Spectrometry", St. Pete's , FL, January 23-26, 2009. | Abstract | Poster |

A. Vertes, P. Nemes, A. A. Barton, B. Shrestha, and  Y. Li, “In vivo analysis and imaging of biological tissue with infrared laser ablation mass spectrometry,” 236th American Chemical Society National Meeting,  Philadelphia, PA, August 17-21, 2008. | Abstract |

B. Shrestha, P. Nemes, J. Nazarian, E. P. Hoffman, and A. Vertes, “Direct analysis of lipids and other metabolites in mouse brain tissue with infrared laser ablation and mass spectrometry,” Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, June 1-5, 2008; DVD-ROM.
| Abstract | Poster |

B. Shrestha, Y. Li, and A. Vertes, “Rapid Analysis of Pharmaceuticals and their Metabolites with Atmospheric Pressure Infrared MALDI Mass Spectrometry”, Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, IN, June 3-7, 2007; DVD-ROM. | Abstract | Poster |

Y. Li, B. Shrestha, and A. Vertes, “Atmospheric Pressure Infrared MALDI Mass Spectrometry: Imaging and In Vivo Studies of Metabolites in Plants”, Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, IN, June 3- 7, 2007; DVD-ROM. | Abstract |

B. Shrestha, Y. Li, and A. Vertes, “Direct analysis of drugs and their metabolites by infrared atmospheric pressure matrix-assisted laser desorption ionization mass spectrometry”, 33rd The Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) Conference, Lake Buena Vista, FL, September 24-28, 2006. | Abstract | Poster |

Y. Li, B. Shrestha, and A. Vertes, “A. Imaging at Atmospheric Pressure by MALDI Mass Spectrometry”, Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics, Seattle, WA, May 28-June 1, 2006, DVD-ROM. | Abstract | Poster |

J. Nazarian, B. Shrestha, Y. Hathout, A. Vertes, and E. P. Hoffman, “Proteomic Analyses of Torpedo Californica Electroplaque as a Model for the Neuromuscular Junction”, Proceedings of the 54th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics, Seattle, WA, May 28-June 1, 2006, DVD-ROM. | Poster |

* The presenting author(s) are underlined.

About me

I am a Ph.D. candidate at the Chemistry Department of the George Washington University (GWU), Washington DC. My research director is Professor Akos Vertes.

Before enrolling in GWU, I graduated from Moravian College , Bethlehem , PA with double major in Chemistry and Economics.


News & highlights

March 2008

Biophotonics featured a report on metabolite analysis by AP IR-MALDI - Deeper Into The Plant Kingdom .

January 2008

Our article was featured on the cover page of the Analytical Chemistry (January 15, 2008 / Volume 80 / Issue 2).

Analytical Chemistry Cover Jan 15, 2008


Peer Reviewed Publications

B. Shrestha, Y. Li, and A. Vertes, “Rapid analysis of pharmaceuticals and excreted xenobiotic and endogenous metabolites with atmospheric pressure infrared MALDI mass spectrometry”, Metabolomics, 2008, 4, 297-311.(DOI: 10.1007/s11306-008-0120-8)

A. Vertes, P. Nemes, B. Shrestha, A. A. Barton, Z. Chen, and Y. Li,”Molecular Imaging by Mid-IR Laser Ablation Mass Spectrometry,” Applied Physics A, 2008, 93, 885-891.
(DOI: 10.1007/s00339-008-4750-5)

Y. Li, B. Shrestha, and A. Vertes, “Atmospheric Pressure Infrared MALDI Imaging Mass Spectrometry for Plant Metabolomics,” Analytical Chemistry, 2008, 80, 407-420. (DOI: 10.1021/ac701703f)

Y. Li, B. Shrestha, and A. Vertes, "Atmospheric Pressure Molecular Imaging by Infrared MALDI Mass Spectrometry," Analytical Chemistry,2007, 79, 523-532. (DOI: 10.1021/ac061577n)

 
Any comments, email me at bindesh(AT)gwmail.gwu.edu
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