Laboratory Members

Lab Group Picture, Fall 2006
Front Courtyard of Ross Hall
George Washington University
2300 Eye St., NW, Washington DC

Several Senior Scientists, Post-Doctoral Fellows, and Undergraduate and Graduate Students are currently working in Dr. Bouscarel's laboratory. Additionally, Dr. Bouscarel supports semester rotational research for Graduate Students in the Institute for Biomedical Sciences (IBS) Ph.D. Program, as well as research for Medical Students and Fellows.

For more information on openings in Dr. Bouscarel's laboratory, visit our Opportunities webpage and/or contact Dr. Bouscarel (see Contact Us page for contact information). Brief descriptions of the research being performed by Senior Scientists, Post-Doctoral Fellows, and Graduate Students currently working in the laboratory are provided below.

Dr. Bernard Bouscarel
Senior Scientists & Post-Doctoral Fellows
Graduate Students

Dr. Bernard Bouscarel:
	Dr. Bernard Bouscarel, Ph.D. 1985, D.Sc. 1995, University of Toulouse, France Associate Professor of Biochemistry and Molecular Biology and of Medicine Director, Digestive Diseases Center Director, Molecular Medicine IBS Program

The Bouscarel laboratory's research program focuses on the molecular mechanism of of transmembrane signal transduction by cell-surface receptors called G protein-coupled receptors (GPCRs). GPCRs allow communication between the outer and inner cell domain and trigger cellular responses. One of the signaling pathways under study includes the glucagon GPCR. This receptor is involved in the regulation of glycogen and glucose metabolism in the liver and its response is altered in certain liver diseases, including cholestasis and cirrhosis. Using proteomic, fluorescent imaging, and biochemical, as well as pharmacological approaches, our goal is to understand what controls receptor expression, down-regulation and activity under physiologic and pathological conditions. Furthermore, The Bouscarel lab’s research program focuses on the mechanism of action and side effects associated to topoisomerase I inhibitors. Topoisomerase I enzymes are involved in DNA synthesis and their inhibition leads to DNA strand breaks and apoptosis. Using a variety of colonic cell lines, our goal is to understand the mechanism regulating Topo I-inhibition-induced apoptosis and the ability of certain agents and drugs to control the shift between apoptosis and necrosis. Finally, The Bouscarel lab’s research program focuses on bile acids and their role in the modulation of hormonal response and the potency of anticancer drugs. The main goal is to identify novel targets useful in the development of new strategies in the treatment of liver diseases and cancer therapy.

Senior Scientists & Post-Doctoral Fellows:
	Jianping Meng, GWU, Senior Scientist
	Jianping Meng obtained an M.D. degree from Jilin University, China. She was employed as a post-doctoral and research fellow at NICHD/NIH from 1996 to 2003 and as a research scientist at George Washington University since 2003. She is currently studying signal transduction related to bile acid metabolic disorders and in particular, the regulation of glucagon receptor signaling.

	Teruo Miyazaki, GWU, Post-Doctoral Fellow
	Teruo Miyazaki obtained a Ph.D. degree in biochemistry in 2004 from the University of Tsukuba, Tsukuba, Japan. Teruo also worked as a research fellow in Ibaraki Prefectural Institute of Public Health, Mito, Japan. Teruo's current research interests include investigating the effects of chemotherapeutic agents on the metastasis of colon cancer and the side effects of these agents in experimental animal models. He has also examined the effectiveness of taurine and its transporter on liver diseases.

Graduate Students:
	Maryam Alrashid, GWU, Ph.D. Student Institute for Biomedical Sciences,
	Maryam studied at Kuwait University and received her B.S. degree in Biochemistry in 1997. She subsequently studied at George Washington University and earned a Master's in Biochemistry in 2001. She entered into the Ph.D. program in Oncology in the IBS at George Washington University in 2001 and is currently investigating the role of nuclear receptors and their ligands in colorectal cancer.

	Lada Krilov, GWU, Ph.D. Student Institute for Biomedical Sciences,
	Lada Krilov received a Bachelor's of Science in Biology from the University of Zagreb in 2002. In Dr. Bouscarel's laboratory, she is studying mechanisms of glucagon receptor desensitization, internalization, and post-endocytic sorting. She defended her Ph.D. dissertation in March, 2007 and plans to graduate from George Washington University in May, 2007.

	Amy Nguyen, GWU, Ph.D. Student Institute for Biomedical Sciences,
	Amy received her Bachelor's of Science in Biology from Shepherd University in 2000. She received her Master's of Science Degree in Biotechnology from Johns Hopkins University in 2005. In Dr. Bouscarel's laboratory, she is currently studying regulation, recycling, and degradation mechanisms of the glucagon receptor.

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Laboratory Members Lab Group Picture, Fall 2006 Front Courtyard of Ross Hall George Washington University 2300 Eye St., NW, Washington DC

Dr. Bernard Bouscarel Senior Scientists & Post-Doctoral Fellows Graduate Students

Dr. Bernard Bouscarel:

Senior Scientists & Post-Doctoral Fellows:

Graduate Students:

Laboratory Members

Lab Group Picture, Fall 2006
Front Courtyard of Ross Hall
George Washington University
2300 Eye St., NW, Washington DC

Dr. Bernard Bouscarel
Senior Scientists & Post-Doctoral Fellows
Graduate Students